DLAT
dihydrolipoamide S-acetyltransferase
Synonimy:
DLTA, PDC-E2, PDCE2
Gatunek:
Human DLAT (1737), Mouse Dlat (235339), Rat Dlat (81654), Zebrafish dlat (324201), domestic cat DLAT (101094126), cow DLAT (512723), Horse DLAT (100062027), dog DLAT (489406), chicken DLAT (419796), naked mole-rat Dlat (101698667) ...Więcej
Identyfikator UniProtKB:
Identyfikator genu:
- Human(1737) Summary: This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009]
- Mouse(235339) dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
- Rat(81654) dihydrolipoamide S-acetyltransferase
- Zebrafish(324201) dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
- domestic cat(101094126) dihydrolipoamide S-acetyltransferase
- cow(512723) dihydrolipoamide S-acetyltransferase
- Horse(100062027) dihydrolipoamide S-acetyltransferase
- dog(489406) dihydrolipoamide S-acetyltransferase
- chicken(419796) dihydrolipoamide S-acetyltransferase
- naked mole-rat(101698667) dihydrolipoamide S-acetyltransferase
- domestic guinea pig(100735563) dihydrolipoamide S-acetyltransferase
- sheep(101110965) dihydrolipoamide S-acetyltransferase
- Domestic Rabbit(100349212) dihydrolipoamide S-acetyltransferase
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Antibodies
Product Number
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-DLAT, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
western blot
western blot
Anti-DLAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-DLAT antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
western blot
western blot
Anti-DLAT antibody produced in rabbit, IgG fraction of antiserum,
Reaktywność gatunkowa
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Zastosowanie
immunohistochemistry
western blot
western blot
Przeciwciało anty-DLAT, klon 2Z7R10, królicze monoklonalne, ,
Reaktywność gatunkowa
human, rat
Zastosowanie
western blot
esiRNA
Product Number
Opis
Gatunek