M4659

Milrinone

≥97% (TLC), powder, phosphodiesterase type III inhibitor

• Synonym(s): 1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile
• Empirical Formula (Hill Notation): C₁₂H₉N₃O
• CAS Number: 78415-72-2
• Molecular Weight: 211.22
• EC Number: 278-903-6
• MDL number: MFCD00133539
• UNSPSC Code: 41106305
• PubChem Substance ID: 24278060
• NACRES: NA.77

Properties

• Product Name: Milrinone, ≥97% (TLC), powder
• Quality Level: 200
• Assay: ≥97% (TLC)
• form: powder
• color: off-white
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• originator: Sanofi Aventis
• storage temp.: 2-8°C
• SMILES string: CC1=C(C=C(C#N)C(=O)N1)c2ccncc2
• InChI: 1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
• InChI key: PZRHRDRVRGEVNW-UHFFFAOYSA-N
• Gene Information: human ... PDE3A(5139) , PDE3B(5140) , PDE4B(5142) , PDE5A(8654) , PTPRA(5786) ; rat ... Pde3a(50678)

Description

Biochem/physiol Actions

Phosphodiesterase type III inhibitor; cAMP-specific, cGMP-inhibitable; potent cardiotonic, positive inotropic vasodilator.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves