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T-032

Supelco

(−)-Δ8-THC solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C21H30O2
CAS Number:
5957-75-5
Molecular Weight:
314.46
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule D (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

cannabis testing
cannabis testing

format

single component solution

storage temp.

−20°C

InChI

1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h9,12-13,16-17,22H,5-8,10-11H2,1-4H3

InChI key

HCAWPGARWVBULJ-UHFFFAOYSA-N

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General description

A certified solution standard suitable for LC/MS or GC/MS applications in cannabinoid testing, clinical toxicology, forensic analysis, or urine drug testing. Δ8-THC is an impurity in synthetic THC manufacturing processes. Δ8-THC is the double bond isomer of the primary psychoactive ingredient of cannabis called Δ9-tetrahydrocannabinol. This cannabinoid has antiemetic, anxiolytic, appetite-stimulating, and analgesic properties.

Application

The Certified Spiking Solution® is suitable for (−)-Δ8-THC testing by HPLC, GC/MS or LC-MS/MS methods in forensic analysis, clinical toxicology, urine drug testing, and Cannabis potency or impurity profiling testing applications. The Certified Reference Material (CRM) in solution can also be used as follows:
  • Multi-analysis of 11 cannabinoids in biomass and extracts of different cannabis varieties by an HPLC-UV method, following the International Conference on Harmonization (ICH) Tripartite Guideline for Validation of Analytical Procedures
  • Separation and estimation of 13 cannabinoids from different cannabis products using isocratic high-performance liquid chromatography (HPLC) in combination with a diode array detector (DAD)
  • Gas chromatographic-mass spectrometric (GC-MS) analysis of ten main cannabinoids from hemp inflorescences following their silylation and esterification for derivatization
  • Quantification of cannabidiol and Δ9-tetrahydrocannabinol in addition to the identification of minor cannabinoids from human plasma samples using ultra-performance liquid chromatography (UHPLC) combined with triple quadrupole mass spectrometry following a liquid-liquid extraction
  • QuEChERS based extraction of 15 cannabinoids from 20 food product samples followed by their quantification by liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Features and Benefits

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

51.8 °F - closed cup

Flash Point(C)

11.0 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ketan Hippalgaonkar et al.
AAPS PharmSciTech, 12(2), 723-731 (2011-06-04)
The purpose of this study was to investigate the effect of cyclodextrins (CDs) on aqueous solubility, stability, and in vitro corneal permeability of delta-8-tetrahydrocannabinol (Δ(8)-THC). Phase solubility of Δ(8)-THC was studied in the presence of 2-hydroxypropyl-β-cyclodextrin (HPβCD), randomly methylated-β-cyclodextrin (RMβCD)
S H Burstein et al.
Life sciences, 56(23-24), 1991-1998 (1995-01-01)
Binding and photoactivation of a cannabinoid-derived ligand to intact mouse peritoneal cells has resulted in the labelling of a G-protein gamma-subunit. The assignment of structure is based on the product's physical characteristics and its ability to react with a polyclonal
S Muchtar et al.
Ophthalmic research, 24(3), 142-149 (1992-01-01)
delta 8-Tetrahydrocannabinol (delta 8-THC), a known antiglaucoma lipophilic drug, was incorporated in a submicron emulsion for ocular administration. The mean droplet size of the emulsion was 130 +/- 41 nm, and no droplet was larger than 400 nm. No change
B R Martin et al.
Pharmacology, biochemistry, and behavior, 46(2), 295-301 (1993-10-01)
One aspect of cannabinoid structure-activity relationships (SARs) that has not been thoroughly investigated is the aromatic (A) ring. Although halogenation of the side chain enhances potency, our recent observation that iodination of the A ring also enhanced activity was surprising.
Donna A Whyte et al.
Pharmacology, 85(6), 328-335 (2010-06-03)
The primary cannabinoids, Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and Delta(8)-tetrahydrocannabinol (Delta(8)-THC) are known to disturb the mitochondrial function and possess antitumor activities. These observations prompted us to investigate their effects on the mitochondrial O(2) consumption in human oral cancer cells (Tu183). This epithelial
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