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914436

Sigma-Aldrich

Fmoc-D-Lys(Biotin)-OH

≥95%

Synonym(s):

Nα-(9-Fluorenylmethyloxycarbonyl)-Nε-biotinyl-D-lysine, N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)-D-lysine, Biotinylated Fmoc-protected D-lysine

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About This Item

Empirical Formula (Hill Notation):
C31H38N4O6S
CAS Number:
110990-09-5
Molecular Weight:
594.72
MDL number:
MFCD00270742

Quality Level

100

Assay

≥95%

form

powder

mp

184-190 °C

storage temp.

2-8°C

InChI

1S/C31H38N4O6S/c36-27(15-6-5-14-26-28-25(18-42-26)33-30(39)35-28)32-16-8-7-13-24(29(37)38)34-31(40)41-17-23-21-11-3-1-9-19(21)20-10-2-4-12-22(20)23/h1-4,9-12,23-26,28H,5-8,13-18H2,(H,32,36)(H,34,40)(H,37,38)(H2,33,35,39)/t24-,25+,26+,28+/m1/s1

InChI key

OFIBQNGDYNGUEZ-KAHNYGAISA-N

Application

Fmoc-D-Lys(Biotin)-OH is a modified lysine derivative for the preparation of biotin-labeled peptides by Fmoc SPPS. Fmoc-L-Lys(Biotin)-OH is available as cat# 8.52097.

Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

Other Notes

Identification of Annexin A2 as a target protein for plant alkaloid matrine

Synthesis and Screening of a Library of Re/Tc-Based Amyloid Probes Derived from β-Breaker Peptide

Probing adenosine receptors using biotinylated purine derivatives

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Karin A Stephenson et al.
Bioconjugate chemistry, 19(5), 1087-1094 (2008-04-15)
Through the development and application of a unique approach for producing Re-metallopeptides, a new class of peptide-derived probes that are designed to target beta-amyloid plaques was developed. Derivatives of a class of beta-breaker peptides having the core sequence lvffa or
Dongyao Wang et al.
Chemical communications (Cambridge, England), 53(36), 5020-5023 (2017-04-22)
Matrine is a plant alkaloid and a major active component in the Chinese medical herb Sophora flavescens. Matrine has shown potent anti-cancer activities but its molecular target(s) and mechanism are still unknown. Using the photo-affinity labeling approach, for the first
Probing adenosine receptors using biotinylated purine derivatives.
K A Jacobson
Methods in enzymology, 184, 668-671 (1990-01-01)
K A Jacobson et al.
Biochemical pharmacology, 36(10), 1697-1707 (1987-05-15)
Derivatives of adenosine receptor agonists (N6-phenyladenosines) and antagonists (1,3-dialkyl-8-phenylxanthines) bearing functionalized chains suitable for attachment to other molecules have been reported [Jacobson et al., J. med. Chem. 28, 1334 and 1341 (1985)]. The "functionalized congener" approach has been extended to

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