822855

TSKgel^® SuperSW mAb HTP HPLC Column

phase diol, L × I.D. 15 cm × 4.6 mm, 4 μm particle size

• Synonym(s): TSKgel^® Size Exclusion (SW-Type) HPLC Column
• UNSPSC Code: 41115711

Properties

• material: stainless steel
• Agency: suitable for USP L20; suitable for USP L59
• product line: TSKgel^®
• manufacturer/tradename: Tosoh SuperSW mAb HTP, 22855
• parameter: ≤0.5 M salt concentration; 0-100% aqueous soluble organic solvents; 0.5 mL/min flow rate; 10-30 °C temperature; 80 bar max. pressure
• technique(s): HPLC: suitable
• L × I.D.: 15 cm × 4.6 mm
• matrix: silica particle platform
• matrix active group: diol phase
• particle size: 4 μm
• pore size: 250 Å pore size
• operating pH: 2.5-7.5
• separation technique: size exclusion (SEC)

Description

General description

The TSKgel SuperSW and UltraSW mAb columns consist of three specialized columns designed for the separation and analysis of monoclonal antibodies (mAb). While mAbs can be analyzed using many different modes of HPLC, size exclusion is best for aggregation, dimer, and fragmentation, making it the best method for heterogeneity studies.TSKgel SuperSW mAb HTP columns provide high throughput analysis of mAb monomer and dimer and is UHPLC compatible. These short, narrow bore (15 cm x 4.6 mm ID) silica-based stainless steel columns offer reduced lot-to-lot variation, long column life, reduction of unspecified adsorption, and superior recovery of aggregates. The TSKgel SW mAb HTP columns utilize a unique pore-controlled technology, which produces a shallow calibration curve in the molecular weight region of a typical monoclonal antibody.

Physical form

Shipped in 0.05% NaN3 and 0.1 M Na2SO4 in 0.1 M phosphate buffer, pH 6.7.

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Legal Information

TSKgel is a registered trademark of Tosoh Corporation