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SML3545

Sigma-Aldrich

NVP-RXI570

≥98% (HPLC)

Synonym(s):

1-[3-(Difluoromethyl)isothiazol-5-yl]-3-[2-fluoro-5-(hydroxymethyl)pyridin-4-yl]urea

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About This Item

Empirical Formula (Hill Notation):
C11H9F3N4O2S
CAS Number:
2270879-17-7
Molecular Weight:
318.27
MDL number:
MFCD32067923
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NC1=CC(F)=NC=C1CO)NC2=CC(C(F)F)=NS2

InChI

1S/C11H9F3N4O2S/c12-8-1-6(5(4-19)3-15-8)16-11(20)17-9-2-7(10(13)14)18-21-9/h1-3,10,19H,4H2,(H2,15,16,17,20)

Biochem/physiol Actions

NVP-RXI570 is an orally active, potent, and selective allosteric dual inhibitor of BRM ((SMARCA2) and BRG1 (SMARCA4) that that downregulates BRM-dependent gene expression. NVP-RXI570 exhibits antiproliferative activity in a BRG1 mutant-lung-tumor xenograft model.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers
Journal of medicinal chemistry, 61, 10155-10172 (2018)

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