SML3341
ML-SA5
≥98% (HPLC)
Synonym(s):
N1-(3-Chloro-2-(piperidin-1-yl)phenyl)-N4,N4-dimethylbenzene-1,4-disulfonamide
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About This Item
Empirical Formula (Hill Notation):
C19H24ClN3O4S2
CAS Number:
Molecular Weight:
457.99
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
ML-SA5 is a potent TRPML cation channel agonist that activates whole-endolysosomal TRPML1 (ML1) currents in DMD myoblasts at a higher potency than ML-SA1 (EC50 = 285 nM vs 10 μM). ML-SA5 ameliorates muscular dystrophy in mdx, but not ML1-knockout, mice in vivo (2 or 5 mg/kg/day i.p.) by facilitating sarcolemma repair, thereby reducing skeletal and cardiac muscle damage with no apparent toxicity to the animals.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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