SML3309
DN01
≥98% (HPLC)
Synonym(s):
4-(4-((Dimethylamino)methyl)-2,6-dimethoxyphenyl)-7-fluoro-2-methylisoquinolin-1(2H)-one
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About This Item
Empirical Formula (Hill Notation):
C21H23FN2O3
CAS Number:
Molecular Weight:
370.42
UNSPSC Code:
12352200
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
, White to light brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
DN01 is a potent and selective BRD8 first bromodomain inhibitor (BRD8(1) IC50 = 12 nM; BRD4(1) & BRD9 IC50 ≥10 μM) that serves as a useful chemical probe for the selective engagement of BRD8 and enrichment of native NuA4 complexes.
Certificates of Analysis (COA)
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