SML1454

Otilonium bromide

≥98% (HPLC)

• Synonym(s): N,N-Diethyl-N-methyl-2-[(4-{[2-(octyloxy)benzoyl]amino}benzoyl)oxy]ethanaminium bromide, N,N-Diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]-ethanaminium bromide, Octylonium bromide
• Empirical Formula (Hill Notation): C₂₉H₄₃BrN₂O₄
• CAS Number: 26095-59-0
• Molecular Weight: 563.57
• MDL number: MFCD00211142
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825892

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 5 mg/mL, clear (warmed)
• storage temp.: −20°C
• SMILES string: O=C(NC1=CC=C(C(OCC[N+](CC)(CC)C)=O)C=C1)C2=CC=CC=C2OCCCCCCCC.[Br-]
• InChI: 1S/C29H42N2O4.BrH/c1-5-8-9-10-11-14-22-34-27-16-13-12-15-26(27)28(32)30-25-19-17-24(18-20-25)29(33)35-23-21-31(4,6-2)7-3;/h12-13,15-20H,5-11,14,21-23H2,1-4H3;1H
• InChI key: VWZPIJGXYWHBOW-UHFFFAOYSA-N

Description

General description

Otilonium bromide is an antispasmodic. It contains a red color ACh (acetylcholine) like moiety bound to an aromatic system that ends with an octyl ether.

Biochem/physiol Actions

Otilonium Bromide is a muscarinic receptor antagonist (antimuscarinic). Otilonium Bromide is a quaternary ammonium salt that exerts spasmolytic action selective on the distal gastrointestinal tract. It is used world-wide for the treatment of irritable bowel syndrome (IBS).

Otilonium bromide has the capability to prevent L-type Ca²⁺ channels and colonic contractile activity. It is a tolerable drug as it is absorbed poorly and has very less side effects.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable