SAB4501435

Anti-APBB2 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Amyloid β A4 precursor protein-binding family B member 2, Fe65-like protein
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 83 kDa
• species reactivity: human, mouse
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:40000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: Q92870
• UniProt accession no.: Q92870
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... APBB2(323)

Description

General description

The gene APBB2 (amyloid β precursor protein binding family B member 2) is mapped to human chromosome 4p13.

Immunogen

The antiserum was produced against synthesized peptide derived from human APBB2.

Immunogen Range: 471-520

Biochem/physiol Actions

The gene APBB2 (amyloid β precursor protein binding family B member 2), also referred to as FE65-like 1, encodes an adaptor protein that binds to the cytoplasmic domain of β-amyloid precursor protein (βAPP) and processes it to form β-amyloid (Aβ). Over-expression of APBB2 leads to an accumulation of Aβ in senile plaques seen in patients with Alzheimer′s disease (AD). Mutations in this gene have been associated with AD.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable