P0503
O-Phosphorylethanolamine
Synonym(s):
2-Aminoethyl dihydrogen phosphate, O-Phosphocolamine, O-Phosphoethanolamine, Colaminephosphoric acid
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About This Item
Linear Formula:
NH2CH2CH2OPO3H2
CAS Number:
Molecular Weight:
141.06
Beilstein:
1758916
EC Number:
MDL number:
UNSPSC Code:
12161700
PubChem Substance ID:
NACRES:
NA.25
Recommended Products
form
powder
storage temp.
−20°C
SMILES string
NCCOP(O)(O)=O
InChI
1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)
InChI key
SUHOOTKUPISOBE-UHFFFAOYSA-N
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Application
O-Phosphorylethanolamine has been used:
- in LHC-8 medium as a supplement in culturing the transformed human liver epithelial (THLE)-2 and THLE-3 cells
- in C-reactive protein (CRP) binding sucrose flotation experiment
- to incubate phosphomonoesters with anion-exchange chromatography (AEC) fractions for the detection of phosphatase activity
- to add in the washed beads for the preparation of phosphorylethanolamine (Pet) -conjugated sepharose column for chromatographic purification of mutant CRP
Biochem/physiol Actions
Phosphorylethanolamine participates in phospholipid metabolism. Its release can be stimulated occasionally by depolarizing stimuli. Reduction of phosphorylethanolamine levels has been observed in Alzheimer′s and Huntington′s disease.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Phosphoethanolamine-complexed C-reactive protein: a pharmacological-like macromolecule that binds to native low-density lipoprotein in human serum
Singh SK, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 394(1-2), 94-98 (2008)
The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection
Gang TB, et al.
Test, jbc-M112 (2012)
Novel Phospholipase A activity secreted byLegionella species
Flieger A, et al.
Journal of Bacteriology, 182(5), 1321-1327 (2000)
Phosphoethanolamine and ethanolamine are decreased in Alzheimer's disease and Huntington's disease
Ellison David W, et al.
Brain Research, 417(2), 389-392 (1987)
Alessandra Tata et al.
Analytical chemistry, 84(15), 6341-6345 (2012-06-30)
The ability of nanoassisted laser desorption-ionization mass spectrometry (NALDI-MS) imaging to provide selective chemical monitoring with proper spatial distribution of lipid profiles from tumor tissues after plate imprinting has been tested. NALDI-MS imaging identified and mapped several potential lipid biomarkers
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