P0033

ProTx-II

≥95% (HPLC)

• Synonym(s): PT-II, ProToxin-II
• Empirical Formula (Hill Notation): C₁₆₈H₂₅₀N₄₆O₄₁S₈
• Molecular Weight: 3826.59
• UNSPSC Code: 51111800

Properties

• Assay: ≥95% (HPLC)
• form: lyophilized solid
• storage condition: under inert gas
• color: white
• storage temp.: −20°C

Description

Biochem/physiol Actions

ProTx-II is a potent, selective Nav1.7 blocker.

ProTx-II is a potent, selective Nav1.7 blocker. Voltage-gated sodium channels (Nav) are responsible for transducing extracellular signals into action potentials in excitable cells. The Nav1 family consists of nine sub-types for which selective tools are highly valued. Discovery of subtype-selective tools has been challenging due to conservation of putative binding sites. Nav1.7 is expressed in sensory neurons and is critical for pain processing. ProTx-II, isolated from the tarantula Thrixopelma pruriens, is a potent blocker of Nav1 channels. Although ProTx-II blocks several members of this channel family, it has >100-fold selectivity for Nav1.7. ProTx-II is active in an in vitro model of pain processing. ProTx-II binds to a previously unknown site on the channel, conferring selectivity and increasing its value as a research tool. It blocks Nav1.7 by decreasing conductance and shifting the activation potential in the positive direction, resulting in an overall decrease in excitability.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable