H1038
Hck human
recombinant, expressed in E. coli BL21, vial of ≥200 units
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About This Item
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recombinant
expressed in E. coli BL21
Quality Level
form
solution
specific activity
1-2 unit/μg protein
packaging
vial of ≥200 units
relevant disease(s)
cancer (leukemia)
shipped in
dry ice
storage temp.
−70°C
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Application
Hck is a protein-tyrosine kinase that is expressed in hemopoietic cells. It is used in leukemia research .
Biochem/physiol Actions
Hck is a member of the Src tyrosine kinase family. Hck has been shown to associate with and be activated by Bcr-Abl, which is a protein-tyrosine kinase that is expressed in chronic myelogenous leukemia .
Unit Definition
One unit will phosphorylate 1.0 picomole of Tyr15 of the peptide substrate pcdc2 6-20 per minute at 30 °C at pH 7.4.
Physical form
Supplied as a solution in 50 mM Tris HCl, pH 7.4, 1 mM EDTA and 1 mM DTT
Storage Class Code
10 - Combustible liquids
Certificates of Analysis (COA)
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J M Lionberger et al.
The Journal of biological chemistry, 275(24), 18581-18585 (2000-06-13)
Bcr-Abl is the constitutively active protein-tyrosine kinase expressed as a result of the Philadelphia translocation in chronic myelogenous leukemia. Bcr-Abl is coupled to many of the same signaling pathways normally regulated by hematopoietic cytokines. Recent work shows that Hck, a
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