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C1728

Anti-Calcium Channel (α_1D Subunit) (L-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit

Name: Anti-Calcium Channel (α<SUB>1D</SUB> Subunit) (L-type of Voltage-gated Ca<SUP>2+</SUP> Channel) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-CACH3, Anti-CACN4, Anti-CACNL1A2, Anti-CCHL1A2, Anti-Cav1.3, Anti-PASNA, Anti-SANDD

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About This Item

MDL number:

MFCD02095953

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse, rat

technique(s)

immunocytochemistry: 1:30-1:150
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:100-1:200

UniProt accession no.

Q99246

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CACNA1D(776)
mouse ... Cacna1d(12289)
rat ... Cacna1d(29716)

Immunogen

synthetic peptide corresponding to amino acids 859-875 of rat α_1D (Accession P27732). This epitope is highly conserved in human and hamster.

Application

Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit is suitable for the following applications:

immunocytochemistry at a dilution of 1:30-1:150
immunoprecipitation
western blot (chemiluminescent) at a dilution of 1:100-1:200

Biochem/physiol Actions

Ca_v1.3 also known as the calcium channel, voltage-dependent, L type, α1D subunit (CACNA1D), is a human gene. It responds more sensitively to depolarization than those of Ca_v1.2 or Ca_v3.1. Ca_v1.3 is required for proper hearing as well as sinoatrial node and brain function. It undergoes extensive alternative splicing. Alternative splicing in the C terminus and drastically modifies gating properties of the channel. The L-type calcium channel Ca_v1.3 is important in human glucose-induced insulin secretion and common variants in CACNA1D may contribute to type 2 diabetes.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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C-terminal alternative splicing of CaV1.3 channels distinctively modulates their dihydropyridine sensitivity.

Hua Huang et al.

Molecular pharmacology, 84(4), 643-653 (2013-08-09)

The transcripts of L-type voltage-gated calcium channels (CaV) 1.3 undergo extensive alternative splicing. Alternative splicing, particularly in the C terminus, drastically modifies gating properties of the channel. However, little is known about whether alternative splicing could modulate the pharmacologic properties

Differential regulation of nimodipine-sensitive and -insensitive Ca2+ influx by the Na+/Ca2+ exchanger and mitochondria in the rat suprachiasmatic nucleus neurons.

Pi-Cheng Cheng et al.

Journal of biomedical science, 25(1), 44-44 (2018-05-24)

Transmembrane Ca2+ influx is critical for molecular rhythmicity, metabolic activity, and neuropeptide release in the central clock of the suprachiasmatic nucleus (SCN). We previously reported that both the Na+/Ca2+ exchanger (NCX) and mitochondria play a role in regulating intracellular Ca2+

Two CD1 genes map to the chicken MHC, indicating that CD1 genes are ancient and likely to have been present in the primordial MHC.

Jan Salomonsen et al.

Proceedings of the National Academy of Sciences of the United States of America, 102(24), 8668-8673 (2005-06-09)

CD1 molecules play an important role in the immune system, presenting lipid-containing antigens to T and NKT cells. CD1 genes have long been thought to be as ancient as MHC class I and II genes, based on various arguments, but

Differential calcium signaling mediated by voltage-gated calcium channels in rat retinal ganglion cells and their unmyelinated axons.

Allison Sargoy et al.

PloS one, 9(1), e84507-e84507 (2014-01-15)

Aberrant calcium regulation has been implicated as a causative factor in the degeneration of retinal ganglion cells (RGCs) in numerous injury models of optic neuropathy. Since calcium has dual roles in maintaining homeostasis and triggering apoptotic pathways in healthy and

Molecular cloning of multiple subtypes of a novel rat brain isoform of the alpha 1 subunit of the voltage-dependent calcium channel.

A Hui et al.

Neuron, 7(1), 35-44 (1991-07-01)

Several cDNAs encoding an isoform of the alpha 1 subunit of the voltage-dependent calcium channel were isolated from rat brain cDNA libraries. The complete nucleotide sequence of 6975 bp encodes a protein of 1634 amino acids, which corresponds to an

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