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86614

Sigma-Aldrich

Tetraethylammonium chloride

BioUltra, for molecular biology, ≥99.0% (AT)

Synonym(s):

Etamon chloride, TEAC, TEA chloride

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About This Item

Linear Formula:
(C2H5)4N(Cl)
CAS Number:
56-34-8
Molecular Weight:
165.70
Beilstein:
3563247
EC Number:
200-267-5
MDL number:
MFCD00011828
UNSPSC Code:
12352107
PubChem Substance ID:
57653171
NACRES:
NA.26

grade

for molecular biology

Quality Level

100

product line

BioUltra

Assay

≥99.0% (AT)

form

powder

mol wt

165.70 g/mol

technique(s)

gas chromatography (GC): suitable

impurities

DNases, none detected
 RNases, none detected
 insoluble matter, passes filter test
 phosphatases, none detected
 proteases, none detected

solubility

H2O: 1 M at 20 °C, clear, colorless

anion traces

bromide (Br-): ≤500 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

1 M in H2O

UV absorption

λ: 260 nm Amax: 0.03
λ: 280 nm Amax: 0.03

SMILES string

[Cl-].CC[N+](CC)(CC)CC

InChI

1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1

InChI key

YMBCJWGVCUEGHA-UHFFFAOYSA-M

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General description

Tetraethylammonium (TEA), a simple quaternary ammonium compound, is commonly used to block potassium channels. It can physically enter the pore and block the channel. Additionally, TEA either imitates or antagonizes the actions of choline and acetylcholine, two other quaternary ammonium ions.

Application

Tetraethylammonium chloride has been used:

  • as a pharmacological agent in electrophysiology to study its pharmacological effects on Cnidarians
  • as a component in refolding buffer for protein refolding
  • to puff onto isolated patches to block voltage-gated K+ (Kv3) channels and post-hoc evaluation

Features and Benefits

  • Assay: ≥99.0% (AT), BioUltra, for molecular biology
  • Suitable for gas chromatography (GC)

Other Notes

TEACl method of DNA-DNA hybridization

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

201.2 °F - closed cup

Flash Point(C)

94 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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International immunopharmacology, 29(1), 21-26 (2015-05-06)
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The open state of voltage-gated potassium (Kv) channels is associated with an increased stability relative to the pre-open closed states and is reflected by a slowing of OFF gating currents after channel opening. The basis for this stabilization is usually
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