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Key Documents

D2205000

Dimetindene maleate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

N,N-Dimethyl-2-{3-[(RS)-1-(pyridine-2-yl)ethyl]-1H-inden-2-yl}ethanamin-(Z)-butendioate

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About This Item

Empirical Formula (Hill Notation):
C20H24N2 · C4H4O4
CAS Number:
3614-69-5
Molecular Weight:
408.49
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

dimetindene

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

SWECWXGUJQLXJF-BTJKTKAUSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dimetindene maleate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Anaphylactic shock caused by buffalo's mozzarella cheese.
Sigrid M C Broekaert et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 101(1), 105-107 (2008-08-07)
V K Kouritas et al.
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 45(2), 113-119 (2010-10-01)
To investigate whether surgical trauma in a rabbit adhesion formation model and the administration of normal saline (N/S), icodextrin (ID) and/or dimetindene maleate (DM) changes the permeability of the normal rabbit parietal peritoneum. A total of 45 female rabbits were
Wilna J Moree et al.
Journal of medicinal chemistry, 52(17), 5307-5310 (2009-08-12)
Analogues of the known H(1)-antihistamine R-dimethindene were profiled as potential agents for the treatment of insomnia. Several highly selective compounds were efficacious in rodent sleep models. On the basis of overall profile, indene 1d and benzothiophene 2a had pharmacokinetic properties
P Mikus et al.
Die Pharmazie, 62(1), 31-33 (2007-02-14)
Cyclodextrin-mediated capillary zone electrophoresis in a hydrodynamically closed separation system with suppressed electroosmotic flow and UV absorbance photometric detection was developed for a high effective separation and quantitation of dimethindene enantiomers in various pharmaceutical formulations (solution, gel, capsules). The running
[Aso an inspection of the family dog is warrented here].
M F Nentwich et al.
MMW Fortschritte der Medizin, 148(42), 5-5 (2007-07-12)
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