372770

HBDDE

A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKC&alpha and PKCγ over PKCδ, βI, and βII isozymes in in vitro assays.

• Synonym(s): HBDDE, 2,2ʹ,3,3ʹ,4,4ʹ-Hexahydroxy-1,1ʹ-biphenyl-6,6ʹ-dimethanol Dimethyl Ether
• Empirical Formula (Hill Notation): C₁₆H₁₈O₈
• CAS Number: 154675-18-0
• Molecular Weight: 338.31
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: orange
• solubility: ethanol: 1 mg/mL; warm water: 1 mg/mL; DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C16H18O8/c1-23-5-7-3-9(17)13(19)15(21)11(7)12-8(6-24-2)4-10(18)14(20)16(12)22/h3-4,17-22H,5-6H2,1-2H3
• InChI key: NEBCAMAQXZIVRE-UHFFFAOYSA-N

Description

General description

A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKC_α (IC₅₀ = 43 µM) and PKC_γ (IC₅₀ = 50 µM) over PKC_δ, β_I, and β_II isozymes in in vitro assays. Reported to induce apoptosis in rodent cerebellar granule neurons.

Protein kinase C (PKC) inhibitor. Selectively inhibits PKC_α (IC₅₀ = 43 µM) and PKC_γ (IC₅₀ = 50 µM) over PKC_δ, βI and βII isozymes.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKCα

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 43 µM against PKCα

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Mathur, A., and Vallano, M.L. 2000. Biochem. Pharmacol.60, 809.
Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable