251700
1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone, Dihydrochloride
Effective irreversible inhibitor of uPA, Factor Xa, and urokinase.
Synonym(s):
1,5-DNS-GGACK, 2HCl
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
off-white
shipped in
ambient
storage temp.
2-8°C
General description
Effective irreversible inhibitor of uPA, Factor Xa, and urokinase. Fluorophore allows direct monitoring of interactions of labeled enzyme. Does not inhibit tPA.
Biochem/physiol Actions
Cell permeable: no
Primary Target
UPA
UPA
Product does not compete with ATP.
Reversible: no
Target IC50: 100 nM for factor Xa
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following initial thaw, aliquot and refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
Reconstitute at 1 mg/ml in 10 mM HCl. Dilute with physiological buffers just prior to use.
Other Notes
Bajaj, S.P., et al. 1992. Proc. Natl. Acad. Sci. USA89, 152.
Bergmeyer, H.V. 1984. Methods Enzym. Anal. 5, 375.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
Bergmeyer, H.V. 1984. Methods Enzym. Anal. 5, 375.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Margaux R Audett et al.
Molecular biology of the cell, 33(1), ar1-ar1 (2021-10-28)
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