860498P

Sphinganine (d18:0)

Avanti Polar Lipids

• Synonym(s): D-erythro-sphinganine
• Empirical Formula (Hill Notation): C₁₈H₃₉NO₂
• CAS Number: 764-22-7
• Molecular Weight: 301.51
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• form: powder
• packaging: pkg of 1 × 10 mg (860498P-10mg); pkg of 1 × 100 mg (860498P-100mg); pkg of 1 × 25 mg (860498P-25mg)
• manufacturer/tradename: Avanti Polar Lipids
• lipid type: sphingolipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC
• InChI: 1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1
• InChI key: OTKJDMGTUTTYMP-ZWKOTPCHSA-N

Description

General description

Sphinganine (d18:0) is a substrate for the enzyme ceramide desaturase. It is synthesized indirectly due to the interconversion of supplemented glycine to serine. Sphinganine (d18:0) is catabolized to ceramide.

Application

Sphinganine (d18:0) has been used:

• as a standard in liquid chromatography tandem mass spectrophotometry for the quantification of epidermal ceramides
• as a medium supplement to test its effect on growth of yeast cells
• in the preparation of bovine serum albumin lipid complex to investigate its effect on non-lysosomal - glucosylceramidase β2 (GBA2) inhibition

Biochem/physiol Actions

Sphinganine (d18:0) levels are not altered in hereditary sensory neuropathy type 1 cells. Accumulation of d18:0 is observed in tumor hypoxia. It is useful as a biomarker for studying microbial diversity.

Packaging

5 mL Amber Glass Screw Cap Vial (860498P-100mg)

5 mL Amber Glass Screw Cap Vial (860498P-10mg)

5 mL Amber Glass Screw Cap Vial (860498P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable