261610

Cyanogen bromide solution

5.0 M in acetonitrile

• Synonym(s): Bromine cyanide, Bromine monocyanide, Bromocyanide, Bromocyanogen, Carbononitridic bromide, Cyanic bromide, Cyanobromide, Cyanogen monobromide
• Linear Formula: BrCN
• CAS Number: 506-68-3
• Molecular Weight: 105.92
• Beilstein: 1697296
• MDL number: MFCD00011597
• UNSPSC Code: 12352100
• PubChem Substance ID: 57648163
• NACRES: NA.22

Properties

• form: liquid
• Quality Level: 200
• concentration: 5.0 M in acetonitrile
• solubility: alcohol: freely soluble(lit.); diethyl ether: freely soluble(lit.); water: freely soluble(lit.)
• density: 1.093 g/mL at 25 °C
• storage temp.: 2-8°C
• SMILES string: BrC#N
• InChI: 1S/CBrN/c2-1-3
• InChI key: ATDGTVJJHBUTRL-UHFFFAOYSA-N

Description

General description

Cyanogen bromide solution induces template-guided condensation of oligonucleotides only in the presence of N-substituted morpholines. Mechanism of the phosphomonoester group activation by cyanogen bromide in N-substituted morpholine buffers has been investigated.

Application

Cyanogen bromide is a general reagent used to cleave carbon-heteroatom bonds. It is used in the synthesis of organocyanamides from corresponding tertiary amines, which is popularly known as von Braun reaction. CNBr solution is widely used in protein immobilization and cleavage.

Safety Information

• Pictograms: GHS02,GHS05,GHS06,GHS09
• Signal Word: Danger
• Hazard Statements: H225 - H300 + H310 + H330 - H314 - H400
• Precautionary Statements: P210 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B
• Supplementary Hazards: EUH032
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 42.8 °F - closed cup
• Flash Point(C): 6 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves