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Key Documents

134708

Sigma-Aldrich

2-Bromo-2-nitro-1,3-propanediol

98%

Synonym(s):

BNPD, BNPK, Bronopol

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About This Item

Linear Formula:
HOCH2C(Br)(NO2)CH2OH
CAS Number:
Molecular Weight:
199.99
Beilstein:
1705868
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

98%

form

crystals

mp

130-133 °C (lit.)

solubility

H2O: soluble 100 mg/mL, clear, colorless to faintly yellow

SMILES string

OCC(Br)(CO)[N+]([O-])=O

InChI

1S/C3H6BrNO4/c4-3(1-6,2-7)5(8)9/h6-7H,1-2H2

InChI key

LVDKZNITIUWNER-UHFFFAOYSA-N

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Application

  • Effect of leave-on cosmetic antimicrobial preservatives on healthy skin resident Staphylococcus epidermidis.: This study examines the impact of various antimicrobial preservatives, including 2-Bromo-2-nitro-1,3-propanediol, on the microbiota of healthy skin, particularly focusing on Staphylococcus epidermidis. The findings suggest that such preservatives can influence the skin′s microbial balance, which is essential for maintaining skin health (Zhang et al., 2023).
  • Assessing the residual antibacterial activity of clinical materials disinfected with glutaraldehyde, o-phthalaldehyde, hydrogen peroxide or 2-bromo-2-nitro-1,3-propanediol by means of a bacterial toxicity assay.: This research assesses the residual antibacterial effects of various disinfectants, including 2-Bromo-2-nitro-1,3-propanediol, on clinical materials, contributing to improved disinfection protocols in healthcare settings (Lerones et al., 2004).
  • Development and testing of a microbiological assay to detect residual effects of disinfectant on hard surfaces.: This study developed a microbiological assay to evaluate the residual effects of disinfectants, including 2-Bromo-2-nitro-1,3-propanediol, on hard surfaces, aiming to enhance surface disinfection strategies in various industries (Mariscal et al., 1999).

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

4.1B - Flammable solid hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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2-Bromo-2-nitro-1, 3-propanediol (Bronopol) and its derivatives: Synthesis, properties, and application (a review).
Legin, G. Ya.
Pharmaceutical Chemistry Journal, 30(4), 273-284 (1996)
František Bílek et al.
Colloids and surfaces. B, Biointerfaces, 88(1), 440-447 (2011-08-06)
Low-density polyethylene (LDPE) samples were treated in air plasma discharge, coated by polyallyamine brush thought copolymeric grafting surface-from reaction and deposited four common antibacterial agents (benzalkonium chloride, bronopol, chlorhexidine and triclosan) to gain material with active antibacterial properties. Surface characteristics
M Matczuk et al.
International journal of cosmetic science, 34(5), 451-457 (2012-05-23)
Bronopol (2-bromo-2-nitropropane-1,3-diol) is used as preservative in cosmetic industry. Its main role in commercial products consists in protection of the cosmetic composition stability by inhibiting the development of micro-organisms. Unfortunately, preservatives can also undergo the degradation processes. The aim of
Heisuke Oono et al.
Biocontrol science, 12(4), 145-148 (2008-01-18)
This study compared the antifungal activities of bronopol and 2-methyl-4-isothiazolin-3-one (MT) against members of the genus Saprolegnia in the family saprolegniaceae, which have the ability to infect fish. The minimum inhibitory concentration of bronopol was 100-200 mg/l but for MT
Lars Bendahl et al.
Journal of pharmaceutical and biomedical analysis, 40(3), 648-652 (2006-01-19)
Ultra performance liquid chromatography (UPLC) was coupled to inductively coupled plasma mass spectrometry (ICP-MS) for fast analysis of three bromine-containing preservatives, monitoring the 79Br and 81Br isotopes simultaneously. Due to the efficiency of the 1.7 microm column packing material, the

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