C2313
Compound 48/80
powder, hypotensive agent
Synonym(s):
Poly-p-methoxyphenethylmethylamine
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About This Item
UNSPSC Code:
41106300
NACRES:
NA.77
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General description
Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.
Application
Compound 48/80 has been used:
- to stimulate hemocytes for histamine release for measurement in ELISA and flow cytometry
- to induce mast cell degranulation
- to induce anaphylactic activity, dermatitis, pruritis, inflammation in mice
Biochem/physiol Actions
Compound 48/80 (C 48/80) is a hypotensive agent, which promotes release of histamine. C 48/80 reduces the phagocytic ability of hemocytes in Styela plicata. C 48/80 promotes degranulation of mast cells. It Inhibits calmodulin, phospholipase C, endoplasmic reticulum (ER) Ca2+ ATPase and activates G proteins.
Preparation Note
Condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Compound 48/80 and 14C-labeled compound 48/80 were synthesized, and fractionated by thin-layer chromatography into 14 components (A-N) with various histamine releasing activities and different Ca2+ requirements for their actions. The histamine release induced from rat mast cells in vitro by
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