K2628

Ketotifen fumarate salt

≥99% (TLC), powder, H₁ histamine receptor antagonist

• Empirical Formula (Hill Notation): C₁₉H₁₉NOS · C₄H₄O₄
• CAS Number: 34580-14-8
• Molecular Weight: 425.50
• EC Number: 252-100-0
• MDL number: MFCD00079394
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278506
• NACRES: NA.77

Properties

• product name: Ketotifen fumarate salt,
• form: powder
• originator: Novartis
• SMILES string: OC(=O)\C=C\C(O)=O.CN1CCC(\CC1)=C2/c3ccccc3CC(=O)c4sccc24
• InChI: 1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
• InChI key: YNQQEYBLVYAWNX-WLHGVMLRSA-N
• Gene Information: human ... HRH1(3269) , PDE7B(27115)

Description

General description

Ketotifen fumarate salt is an antihistamine drug.

Application

Ketotifen fumarate salt has been used: for mast cell product antagonism, as a positive control in β-hexosaminidase release assay, as mast cell stabilizer to treat pregnant dams added to ad libitum drinking water

Biochem/physiol Actions

H₁ histamine receptor antagonist.

Ketotifen fumarate plays a key role in preventing histamine release by blocking the histamine H1 receptors. It interferes with the release of histamine, serotonin and other inflammatory mediators from mast cells. It exhibits with anti-allergic activity, anti-inflammatory effects including mast cell stabilization. It has been widely used for ophthalmic allergic conjunctivitis.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H319
• Precautionary Statements: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves