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Key Documents

SAB4503674

Sigma-Aldrich

Anti-CD40 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

B-cell surface antigen CD40, Bp50, CD40 antigen, CD40L receptor, CDw40

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 30 kDa

species reactivity

mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P25942

UniProt accession no.

P25942

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CD40(958)

General description

Anti-CD40 Antibody detects endogenous levels of total CD40 protein.
Cluster of differentiation 40 (CD40) is a type I transmembrane glycoprotein. It has a molecular weight of 40 ~ 50kDa and made of 277 amino acids. The CD40 gene is mapped to human chromosome 20q11-13. It has eight introns and nine exons.

Immunogen

The antiserum was produced against synthesized peptide derived from human CD40.

Immunogen Range: 228-277

Application

Anti-CD40, C-Terminal antibody has been used in western blotting.

Biochem/physiol Actions

Cluster of differentiation 40 (CD40) plays a major role in cellular and humoral immunity. It initiates inflammatory response to induce the progression of atherosclerosis.The CD40 pathway participates in the growth and pathogenesis of autoimmune diseases like rheumatoid arthritis (RA).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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CD40 functional gene polymorphisms and mRNA expression in rheumatoid arthritis patients from western Mexico
Roman-Fernandez IV, et al.
Genetics and molecular research : GMR (2016)
Yanxia Ning et al.
Metabolism: clinical and experimental, 71, 83-93 (2017-05-20)
Oxysterol sulfation plays a fundamental role in the regulation of many biological events. Its products, 25-hydroxycholesterol 3-sulfate (25HC3S) and 25-hydroxycholesterol 3, 25-disulfate (25HCDS), have been demonstrated to be potent regulators of lipid metabolism, inflammatory response, cell apoptosis, and cell survival.
Single nucleotide polymorphisms in the CD40 gene associate with the disease susceptibility and severity in knee osteoarthritis in the Chinese Han population: a case-control study
Deng ZH, et al.
BMC Musculoskelet. Disord., 18(1), 115-115 (2017)

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