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246R-1

Sigma-Aldrich

E-cadherin (EP700Y) Rabbit Monoclonal Primary Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP700Y, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (246R-14)
vial of 0.5 mL concentrate (246R-15)
bottle of 1.0 mL predilute (246R-17)
vial of 1.0 mL concentrate (246R-16)
bottle of 7.0 mL predilute (246R-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

isotype

IgG

control

breast

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

General description

E-cadherin is a transmembrane protein that is involved in cell adhesion through the formationof adherens junctions between cells. It is expressed in cells of epithelial lineage. Anti-E-cadherin stains positively in the glandular epithelium as well as carcinomas of the gastrointestinaltract and breast. E-cadherin immunohistochemistry may also aid in the differentiation ofbreast ductal carcinomas (with membranous stain) from lobular carcinomas (with loss of themembranous stain).

Quality


IVD
IVD
IVD
RUO

Linkage

E-cadherin Positive Control Slides, Product No. 246S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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A J Karayiannakis et al.
Hepato-gastroenterology, 45(24), 2437-2442 (1999-02-10)
E-cadherin is a cell-cell adhesion molecule involved in tumor progression and metastasis. We evaluated the E-cadherin expression pattern in gastric cancer and investigated its relationship to histopathological features. The expression of E-cadherin was evaluated in 83 formalin-fixed, paraffin-embedded specimens of
A C Han et al.
Human pathology, 28(6), 641-645 (1997-06-01)
The differential diagnosis of pleural mesotheliomas and lung adenocarcinomas presents a continued challenge in the practice of surgical pathology. Paraffin immunohistochemistry (IHC) using different panels of antibodies can be helpful in some cases, but, as yet, no antigen is expressed
A Peralta Soler et al.
Human pathology, 28(6), 734-739 (1997-06-01)
This study examines the expression of E-cadherin and N-cadherin in the most common epithelial tumors of the ovary. The homotypic interactions of distinctive members of the cadherin family of cell-cell adhesion molecules segregate cells into tissues during embryonic development, and
G Acs et al.
American journal of clinical pathology, 115(1), 85-98 (2001-02-24)
We studied the pattern of E-cadherin expression in 183 invasive carcinomas (100 ductal, 42 lobular, 41 with mixed ductal and lobular features) and 198 in situ carcinomas (131 ductal, 53 lobular, 14 in situ with ductal and lobular features) by
A C Han et al.
Cancer, 87(2), 83-86 (1999-05-05)
Cadherins are a family of cell-cell adhesion proteins. The homotypic binding of cadherins is critical for cell sorting and tissue formation during organogenesis. Different cadherin subtypes show lineage specific tissue expression, which has been exploited to differentiate histologically similar tumors
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