930644

VH 032 amide-PEG₂-acid

≥95%

• Synonym(s): (S,R.S)-AHPC-PEG₂-acid, (S,R,S)-AHPC-CO-PEG₂-C₂-acid, 3-[2-(2-{[(2S)-1-[(2S,4R)-4-Hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}ethoxy)ethoxy]propanoic acid, L-Prolinamide, N-[3-[2-(2-carboxyethoxy)ethoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
• Empirical Formula (Hill Notation): C₃₀H₄₂N₄O₈S
• CAS Number: 2172820-09-4
• Molecular Weight: 618.74
• MDL number: MFCD32670313
• UNSPSC Code: 12352106
• NACRES: NA.21

Properties

• ligand: VH032
• Quality Level: 100
• Assay: ≥95%
• form: powder
• functional group: carboxylic acid
• storage temp.: 2-8°C

Description

Application

VH 032 amide-PEG₂-acid is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal carboxyl group, allowing rapid conjugation of amine containing linkers. A basic building block for development of a protein degrader library.


Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002)

Other Notes

Targeted Protein Degradation by Small Molecules


Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG


Small-Molecule PROTACS: New Approaches to Protein Degradation


Targeted Protein Degradation: from Chemical Biology to Drug Discovery


Impact of linker length on the activity of PROTACs

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable