T2320

T0901317

≥98%

• Synonym(s): N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
• Empirical Formula (Hill Notation): C₁₇H₁₂NSO₃F₉
• CAS Number: 293754-55-9
• Molecular Weight: 481.33
• MDL number: MFCD03412028
• UNSPSC Code: 12352200
• PubChem Substance ID: 24900032
• NACRES: NA.25

Properties

• Quality Level: 200
• Assay: ≥98%
• mol wt: 481.3
• storage temp.: −20°C
• SMILES string: OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c2ccccc2)(C(F)(F)F)C(F)(F)F
• InChI: 1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
• InChI key: SGIWFELWJPNFDH-UHFFFAOYSA-N
• Gene Information: human ... ABCA1(19) , NR1H2(7376) , NR1H3(10062)

Description

Application

T0901317 has been used in LXR agonist study in order to observe the expression of all dietary cholesterol-regulated genes in mice. It has also been used to stimulate the radiolabeled peritoneal macrophages from WT (wildtype) and Tg (transgenic) mice for cellular cholesterol efflux assay.

Biochem/physiol Actions

T0901317 can prevent the secretion of insulin by acting on the metabolism of mitochondria.

LXR agonist whose treatment results in an LXR-dependent up-regulation of ABC1 gene expression

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves