Skip to Content
Merck
All Photos(1)

Documents

779229

Sigma-Aldrich

(2-Hydroxypropyl)-γ-cyclodextrin

Produced by Wacker Chemie AG, Burghausen, Germany, Life Science

Synonym(s):

Cavasol® W8 HP, HGC

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

CAS Number:
128446-34-4
UNSPSC Code:
12352201
NACRES:
NA.22

grade

Produced by Wacker Chemie AG, Burghausen, Germany, Life Science

form

powder

extent of labeling

0.5-0.7 molar substitution

impurities

≤0.1% propylene glycol (Ph Eur)

loss

≤10.0% loss on drying

pH

6-9 (2% in H2O)

InChI

1S/C51H88O38/c1-14(56)8-73-11-21-42-29(64)36(71)50(81-21)85-40-19(6-54)79-48(34(69)27(40)62)89-44-23(13-75-10-16(3)58)82-51(37(72)30(44)65)86-41-20(7-55)78-47(33(68)26(41)61)88-43-22(12-74-9-15(2)57)80-49(35(70)28(43)63)84-39-18(5-53)76-45(31(66)24(39)59)83-38-17(4-52)77-46(87-42)32(67)25(38)60/h14-72H,4-13H2,1-3H3/t14?,15?,16?,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1

InChI key

ODLHGICHYURWBS-RYJYQAAZSA-N

Looking for similar products? Visit Product Comparison Guide

General description

(2-Hydroxypropyl)-γ-cyclodextrin (HP-β-CD) is a hydrophilic compound that can be used as a complexing agent to increase the aqueous solubility and dissolution rate of the drug molecule.

Application

For R&D use
HP-β-CD can be utilized to improve the aqueous solubility and dissolution rate of zolpidem (ZP) upon complexation. ZP-HP-β-CD complexes showed improved ataxic activity.
It is also used to enhance the wound healing property of curcumin by increasing the water solubility.

Legal Information

Cavasol is a registered trademark of Wacker Chemie AG

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Complexation of Zolpidem with 2-hydroxypropyl-β -, methyl-β -, and 2-hydroxypropyl-γ -cyclodextrin: Effect on aqueous solubility, dissolution rate, and ataxic activity in rat
Trapani, G, et al.
Journal of Pharmaceutical Sciences, 89(11), 1443-1451 (2000)
Physicochemical study and characterization of the trimethoprim/2-hydroxypropyl-γ -cyclodextrin inclusion complex
Macedo OFL, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 86(11), 101-106 (2012)
Enhancement of curcumin wound healing ability by complexation with 2-hydroxypropyl-γ-cyclodextrin in sacran hydrogel film
Wathoni N, et al.
International Journal of Biological Macromolecules, 98(11), 268-276 (2017)
Rachel J Smith et al.
The European journal of neuroscience, 30(3), 493-503 (2009-08-07)
The orexin/hypocretin system has recently been implicated in reward-processing and addiction. We examined the involvement of the orexin system in cue-induced reinstatement of extinguished cocaine-seeking by administering the orexin 1 receptor antagonist SB-334867 (SB) or the orexin 2 receptor antagonist
D E Rusyniak et al.
Neuroscience, 154(4), 1619-1626 (2008-06-07)
When given in a warm environment MDMA (3,4-methylenedioxymethamphetamine, ecstasy) causes hyperthermia by increasing interscapular brown adipose tissue (iBAT) heat production and decreasing heat loss via cutaneous vasoconstriction. When given in a cold environment, however, MDMA causes hypothermia by an unknown

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service