SML0922

NSC130813

≥98% (HPLC)

• Sinónimos: 4-[(6-Chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-phenol trihydrochloride, F06, NERI02
• Fórmula empírica (notación de Hill): C₂₆H₂₇ClN₄O₂ · 3HCl
• Número de CAS: 1082532-95-3
• Peso molecular: 572.35
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: H₂O: 10 mg/mL, clear
• storage temp.: −20°C

Descripción

Biochem/physiol Actions

NSC130813 blocks protein-protein interactions between XPF and ERCC1, two proteins involved in nucleotide excision repair (NER). The compound, NSC130813, blocks repair of DNA damage induced by platinum-based ctyotoxic drugs and DNA alkylating agents. NSC130813 synergistically potentiates cell death in cancer cell lines treated with cisplatin or mitomycin C.

Other Notes

air sensitive

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable