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Merck
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Documentos

B5774

Supelco

Benzbromarone

analytical standard

Sinónimos:

3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran

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About This Item

Fórmula empírica (notación de Hill):
C17H12Br2O3
Número de CAS:
3562-84-3
Peso molecular:
424.08
EC Number:
222-630-7
MDL number:
MFCD00078962
UNSPSC Code:
41116107
PubChem Substance ID:
329773266
NACRES:
NA.24

grade

analytical standard

Quality Level

200

assay

~95%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CCc1oc2ccccc2c1C(=O)c3cc(Br)c(O)c(Br)c3

InChI

1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3

InChI key

WHQCHUCQKNIQEC-UHFFFAOYSA-N

Gene Information

human ... CYP2C19(1557) , CYP2C9(1559) , SLC22A12(116085)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Choose from one of the most recent versions:

Certificados de análisis (COA)

Lot/Batch Number
SLCK5558
SLBZ8912
038F0014

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Tip W Loo et al.
Biochemistry, 50(21), 4393-4395 (2011-04-28)
Deletion of Phe508 from the first nucleotide-binding domain of the CFTR chloride channel causes cystic fibrosis because it inhibits protein folding. Indirect approaches such as incubation at low temperatures can partially rescue ΔF508 CFTR, but the protein is unstable at
Atsushi Iwamura et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(5), 838-846 (2011-02-16)
Drug-induced hepatotoxicity is a major problem in drug development, and reactive metabolites generated by cytochrome P450s are suggested to be one of the causes. CYP2C9 is one of the major enzymes in hepatic drug metabolism. In the present study, we
Fernanda Cristina Mazali et al.
Nephron. Experimental nephrology, 120(1), e12-e19 (2011-12-01)
Hyperuricemia frequently complicates cyclosporine (CsA) therapy. Previous studies have shown that hyperuricemia exacerbates interstitial and vascular lesions in the cyclosporine model. We tested the hypothesis that normalization of uric acid could prevent the development of cyclosporine toxicity. CsA nephropathy was
Tip W Loo et al.
Biochemical pharmacology, 83(3), 345-354 (2011-12-06)
The most common cause of cystic fibrosis is deletion of Phe508 in the first nucleotide-binding domain (NBD) of the CFTR chloride channel, which inhibits protein folding. ΔF508 CFTR can be rescued by indirect approaches such as low temperature but the
Kaoru Kobayashi et al.
Biopharmaceutics & drug disposition, 33(8), 466-473 (2012-08-31)
Benzbromarone (BBR) is metabolized to 1'-hydroxy BBR and 6-hydroxy BBR in the liver. 6-Hydroxy BBR is further metabolized to 5,6-dihydroxy BBR. The aim of this study was to identify the CYP isozymes involved in the metabolism of BBR to 1'-hydroxy
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