SMB00915

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester)

≥95% (HPLC)

• Sinónimos: BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester), (3α,5β,12β)-3,12-dihydroxy-11-oxo-cholan-24-oic-acid methyl ester
• Fórmula empírica (notación de Hill): C₂₅H₄₀O₅
• Número de CAS: 27240-87-5
• Peso molecular: 420.58
• UNSPSC Code: 41141802
• NACRES: NA.25

Propiedades

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• mp: 153.5—154.5 °C
• solubility: chloroform: 20 mg/mL, colorless to light yellow
• storage temp.: 2-8°C
• SMILES string: O=C(OC)CCC(C)C1CCC2C3CCC4CC(O)CCC4(C)C3C(=O)C(O)C12C

Descripción

General description

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) is a more potent analog of microbiome metabolite BAA485 (12-oxolithocholic acid) that activates the Pyrin inflammasome in myeloid and intestinal epithelial cells. BAA473 potently induces secretion of IL1β and IL18 in LPS-primed PBMCs and THP-1 cells.

Bile acids, natural steroid amphipathic compounds formed through cholesterol oxidation in the liver, play a crucial role in regulating lipid metabolism. They facilitate the digestion, absorption, and transport of lipids, lipid-soluble vitamins, and related molecules in the gastrointestinal tract. These bile acids also impact various aspects of cholesterol, glucose, and energy balance.

Application

BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) finds application in metabolomics, biochemical and microbiome research.

Features and Benefits

• Can be used in Metabolomics and Biochemical research
• High-quality compound suitable for multiple research applications

Other Notes

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Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable