P3075

Phenylarsine oxide

≥97%, powder

• Sinónimos: Arzene, Oxophenylarsine, PAO
• Fórmula empírica (notación de Hill): C₆H₅AsO
• Número de CAS: 637-03-6
• Peso molecular: 168.02
• Beilstein/REAXYS Number: 2935227
• EC Number: 211-275-3
• MDL number: MFCD00001990
• UNSPSC Code: 12352119
• PubChem Substance ID: 24898387
• NACRES: NA.77

Propiedades

• biological source: synthetic (organic)
• assay: ≥97%
• form: powder
• color: white to off-white
• mp: 145-148 °C
• solubility: DMSO: 50 mg/mL
• SMILES string: O=[As]c1ccccc1
• InChI: 1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H
• InChI key: BQVCCPGCDUSGOE-UHFFFAOYSA-N

Descripción

General description

Phenylarsine oxide (PhAsO⁴) is a bifunctional SH group chemical. It is hydrophobic in nature.

Application

Phenylarsine oxide has been used to infuse animals with a nigrostriatal transection, to determine whether peroxovanadium (pVa) would synergize with brain-derived neurotrophic factor (BDNF).

Biochem/physiol Actions

Phenylarsine oxide (PAO) can reduce the motility and sustainability of Setaria cervi. It has the ability to stimulate cyclosporin A-sensitive transition in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid). It acts as a stimulator of mitochondrial ion fluxes.

Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H301 + H331,H410
• pcodes: P261 - P264 - P271 - P273 - P301 + P310 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable