Saltar al contenido
Merck
Todas las fotos(3)

Documentos clave

Ver Toda la documentación

M6751

Sigma-Aldrich

5-Methylcytosine hydrochloride

≥99%

Sinónimos:

4-Amino-2-hydroxy-5-methylpyrimidine

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(3)

About This Item

Fórmula empírica (notación de Hill):
C5H7N3O · HCl
Número de CAS:
58366-64-6
Peso molecular:
161.59
EC Number:
261-223-9
MDL number:
MFCD11053426
UNSPSC Code:
41106305
PubChem Substance ID:
24897110
NACRES:
NA.51
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

synthetic (organic)

Quality Level

200
300

assay

≥99%

form

crystalline powder

solubility

water: 50 mg/mL, clear to slightly hazy, colorless

SMILES string

O=C1NC(N)=C(C)C=N1.[H]Cl

InChI

1S/C5H7N3O.ClH/c1-3-2-7-5(9)8-4(3)6;/h2H,1H3,(H3,6,7,8,9);1H

InChI key

ANWMULVRPAUPJT-UHFFFAOYSA-N

¿Está buscando productos similares? Visita Guía de comparación de productos

Comparar elementos similares

Ver comparación completa

Mostrar Diferencias

1 of 4

Este artículo
BR91253BR91248BR91236
BRAND® glass beaker with spout, low form volume 400 mL, with graduation

BR91241

BRAND® glass beaker with spout, low form

BRAND® glass beaker with spout, low form volume 800 mL, with graduation

BR91253

BRAND® glass beaker with spout, low form

BRAND® glass beaker with spout, low form volume 600 mL, with graduation

BR91248

BRAND® glass beaker with spout, low form

BRAND® glass beaker with spout, low form volume 250 mL, with graduation

BR91236

BRAND® glass beaker with spout, low form

feature

with graduation

feature

with graduation

feature

with graduation

feature

with graduation

manufacturer/tradename

BRAND 91241

manufacturer/tradename

BRAND 91253

manufacturer/tradename

BRAND 91248

manufacturer/tradename

BRAND 91236

volume

400 mL

volume

800 mL

volume

600 mL

volume

250 mL

Application

5-Methylcytosine hydrochloride has been used as standard in high performance liquid chromatography (HPLC) for the estimation of global methylation rates.[1] It has also been used in high-resolution mass spectroscopic analysis.[2]
5-Methylcytosine is used in studies of DNA methylation processes (epigenetics).

Biochem/physiol Actions

5-Methylcytosine mediates gene expression, genomic imprinting and inhibition of transposable elements.[3] It is closely associated with translational fidelity and tRNA recognition.[4]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

    • Elija entre una de las versiones más recientes:

    Certificados de análisis (COA)

    Lot/Batch Number
    MKCQ6089
    MKCM0760
    MKCP1409
    MKCM8004
    MKCM0630

    ¿No ve la versión correcta?

    Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

    Busque por un COA

    ¿Ya tiene este producto?

    Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

    Visite la Librería de documentos

    Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
    Squires JE, et al.
    Nucleic Acids Research, 40(11), 5023-5033 (2012)
    Absolute quantification of RNA or DNA using acid hydrolysis and mass spectrometry
    Lowenthal MS, et al.
    Analytical Chemistry, 6, 824-824 (2019)
    Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
    Ito S, et al.
    Science (New York, N.Y.), 333(6047), 1300-1303 (2011)
    Daniel Renciuk et al.
    Nucleic acids research, 41(21), 9891-9900 (2013-08-22)
    5-Hydroxymethylcytosine (5-hmC) was recently identified as a relatively frequent base in eukaryotic genomes. Its physiological function is still unclear, but it is supposed to serve as an intermediate in DNA de novo demethylation. Using X-ray diffraction, we solved five structures
    Shinpei Yamaguchi et al.
    Cell research, 23(3), 329-339 (2013-02-13)
    Previous studies have revealed that mouse primordial germ cells (PGCs) undergo genome-wide DNA methylation reprogramming to reset the epigenome for totipotency. However, the precise 5-methylcytosine (5mC) dynamics and its relationship with the generation of 5-hydroxymethylcytosine (5hmC) are not clear. Here
    Ver todos los artículos relacionados

    Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

    Póngase en contacto con el Servicio técnico