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L0636

Sigma-Aldrich

Lectin from Triticum vulgaris (wheat)

suitable for cell culture, BioReagent, lyophilized powder

Sinónimos:

WGA, Wheat germ agglutinin

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

sterility

aseptically processed

Quality Level

200

product line

BioReagent

form

lyophilized powder

technique(s)

cell culture | mammalian: suitable

impurities

salt, essentially free

storage temp.

2-8°C

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Este artículo
SML0822M5449SML2465
YM-1

SML0943

YM-1

YM-08 ≥98% (HPLC)

SML0822

YM-08

MKT-077 ≥98% (HPLC), powder

M5449

MKT-077

CY-09 ≥98% (HPLC)

SML2465

CY-09

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

-

solubility

H2O: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

orange to dark red

color

yellow to orange

color

orange to red

color

faint yellow to dark orange

General description

Lectin from Triticum vulgaris (wheat) is a dimeric glycoprotein of 36 kDa.[1] It belongs to the family of chitin-binding proteins. Glycosylated precursor of lectin is synthesized in endoplasmic reticulum.[1]

Application

Lectin from Triticum vulgaris (wheat) has been used:
  • to conjugate with N-hydroxysuccinimide (NHS) dye[2]
  • to inhibit nuclear import[3]
  • to inhibit the nuclear pore of human cervical carcinoma HeLa and SiHa cells[4]

Biochem/physiol Actions

Lectin from Triticum vulgaris (wheat) possessing four binding sites is specific for N-acetyl-d-glucosamine and N-acetyl-d-neuraminic acid (sialic acid) residues.[5] Lectins also function as a fungicide.[1] They also possess anti-nutritive effects.[5]
WGA is not blood group specific but has an affinity for N-acetyl-β-D-glucosaminyl residues and N-acetyl-β-D-glucosamine oligomers. WGA contains no protein-bound carbohydrate.

Other Notes

Highly purified

Preparation Note

Conjugates are prepared from affinity purified lectin.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

    • Elija entre una de las versiones más recientes:

    Certificados de análisis (COA)

    Lot/Batch Number
    SLBW9614
    SLBX8612
    SLBQ6697V
    SLBM7377V
    SLBJ7360V

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    ¿Ya tiene este producto?

    Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

    Visite la Librería de documentos

    Plant lectins: occurrence, biochemistry, functions and applications
    Rudiger H and Gabius HJ
    Glycoconjugate Journal, 18, 589-613 (2001)
    Tsung-Lin Tsai et al.
    International journal of nanomedicine, 7, 5215-5234 (2012-10-17)
    Gold nanoparticles modified with the nuclear localization signal from simian virus 40 large T antigen (GNP-PEG/SV40) accumulate on the cytoplasmic side of the nuclear membrane in HeLa cells. Accumulation of GNP-PEG/SV40 around the nucleus blocks nucleocytoplasmic transport and prevents RNA
    Nuclear localization of Tob is important for regulation of its antiproliferative activity
    Kawamura-Tsuzuku J, et al.
    Oncogene, 23, 6630-6630 (2004)
    Effects of wheat germ agglutinin on human gastrointestinal epithelium: insights from an experimental model of immune/epithelial cell interaction
    Dalla P, et al.
    Toxicology and Applied Pharmacology, 237, 146-153 (2009)
    Super-multiplex vibrational imaging
    Wei L, et al.
    Nature, 544, 465-465 (2017)
    Ver todos los artículos relacionados

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