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Merck

H2504

Sigma-Aldrich

His-Leu

≥98% (TLC), suitable for ligand binding assays

Sinónimos:

histidylleucine

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About This Item

Fórmula empírica (notación de Hill):
C12H20N4O3
Número de CAS:
Peso molecular:
268.31
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

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Nombre del producto

His-Leu,

assay

≥98% (TLC)

Quality Level

form

solid

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(N)Cc1cnc[nH]1)C(O)=O

InChI

1S/C12H20N4O3/c1-7(2)3-10(12(18)19)16-11(17)9(13)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)

InChI key

MMFKFJORZBJVNF-UHFFFAOYSA-N

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Este artículo
P1818P4636P3418
storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

color

white to off-white

color

white to light yellow

color

white to off-white

color

white to off-white

mol wt

15,000-50,000

mol wt

1,500-5,500 by MALLS

mol wt

3,000-15,000

mol wt

2,000-11,000

application(s)

detection

application(s)

cell analysis

application(s)

-

application(s)

-

Biochem/physiol Actions

Histidylleucine (His-Leu); histidylglycine (His-Gly) and histidylserine (His-Ser) are N-terminal imidazole containing dipeptides used to study binding of metals such as copper, nickel and zinc.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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R A Santos et al.
Hypertension (Dallas, Tex. : 1979), 7(2), 244-252 (1985-03-01)
The most sensitive nonradiometric routine assay for angiotensin-converting enzyme (ACE) activity uses fluorometry to detect His-Leu released from Hip-His-Leu. Our results indicate that, in contrast to human serum, rat serum and plasma contain large and variable amounts of dipeptidase activity
J B Vita et al.
Investigative ophthalmology & visual science, 20(2), 255-257 (1981-02-01)
Angiotensin II is a biological active octapeptide that is formed by the action of angiotensin-converting enzyme (ACE) on the inactive precursor, angiotensin I. ACE activity was found in tears and aqueous humor from both rabbit and human eyes. The activity
V Schusdziarra et al.
Peptides, 7(1), 127-133 (1986-01-01)
Bombesin-like immunoreactivity (BLI) has been demonstrated in neurons of the gastrointestinal tract and gastric BLI secretion can be demonstrated in response to the classical neurotransmitter acetylcholine. Since structurally related peptides VIP, PHI and GRF have to be considered as peptidergic
K Iwatsuki et al.
Clinical and experimental pharmacology & physiology, 20(7-8), 501-507 (1993-07-01)
1. The effects of peptide histidine isoleucine (PHI) on pancreatic exocrine secretion were investigated in preparations of the isolated and blood-perfused dog pancreas as compared with those of vasoactive intestinal peptide (VIP), secretin and glucagon. 2. Each peptide tested was
S Ceccatelli et al.
Neuroendocrinology, 49(3), 309-323 (1989-03-01)
The distribution of several peptides, corticotropin-releasing factor (CRF), neurotensin (NT), enkephalin (ENK), vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), cholecystokinin (CCK), thyrotropin-releasing hormone (TRH) and galanin (GAL) was studied in detail with immunohistochemistry in the various subdivisions of the

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