F0881

Fusidic acid sodium salt

≥98% (TLC)

• Sinónimos: Fucidin
• Fórmula lineal: C₃₁H₄₇O₆Na
• Número de CAS: 751-94-0
• Peso molecular: 538.69
• EC Number: 212-030-3
• MDL number: MFCD09054714
• UNSPSC Code: 12352106
• PubChem Substance ID: 24278430
• NACRES: NA.77

Propiedades

• assay: ≥98% (TLC)
• solubility: H₂O: soluble
• antibiotic activity spectrum: neoplastics
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [Na+].C[C@@H]1[C@H](O)CC[C@@]2(C)C1CC[C@@]3(C)C2[C@H](O)CC4\C([C@H](C[C@]34C)OC(C)=O)=C(/CC\C=C(\C)C)C([O-])=O
• InChI: 1S/C31H48O6.Na/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32;/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36);/q;+1/p-1/b26-20-;/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-;/m0./s1
• InChI key: HJHVQCXHVMGZNC-JCJNLNMISA-M

Descripción

General description

Fusidic acid is an antibiotic substance, resembling the structure of a steroid. It belongs to the class of fusidanes.

Application

Fusidic acid sodium salt has been used to study the effects of three-drug combinations on the growth rate of a bacterium, wild-type Escherichia coli. It is also used to study the in vitro susceptibility of dog-derived European methicillin-resistant Staphylococcus pseudintermedius and Staphylococcus aureus strains and their methicillin-susceptible counterparts.

Biochem/physiol Actions

Fusidic acid possesses antimicrobial action against skin pathogens. It is highly specific to Staphylococcus aureus. It is therefore used for treating infected traumatic wounds, folliculitis, furunculosis, impetigo, erythrasma and abscesses.

Suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.

Features and Benefits

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Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves