A7856
Acipimox
≥99% (TLC)
Sinónimos:
2-Carboxy-5-methylpyrazine 4-oxide, 5-Methylpyrazinecarboxylic acid 4-oxide
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About This Item
Fórmula empírica (notación de Hill):
C6H6N2O3
Número de CAS:
Peso molecular:
154.12
EC Number:
UNSPSC Code:
12352205
NACRES:
NA.79
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Quality Level
assay
≥99% (TLC)
form
powder
color
off-white to faint yellow
mp
177-180 °C
storage temp.
2-8°C
InChI
1S/C6H6N2O3/c1-4-2-7-3-5(6(9)10)8(4)11/h2-3H,1H3,(H,9,10)
InChI key
DNRXJHATQULEHC-UHFFFAOYSA-N
Categorías relacionadas
Biochem/physiol Actions
Acipimox, also known as olbemox, is a nicotinic acid analog. It functions as an anti-lipolytic drug and vasodilator. Acipimox may be used in various metabolic studies involving insulin and ghrelin. It lowers total cholesterol and total triglycerides, which helps in the treatment of hyperlipidemia.
Niacin-derived, vasodilator studied for its lipid-lowering effect.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Feipeng Jin et al.
Biochemical and biophysical research communications, 428(1), 86-92 (2012-10-13)
Saturated fatty acids (FA) have been linked to an increased risk of cardiovascular disease. The effects of acipimox, a FA-lowering agent, on palmitate- (an important saturated fatty acid) stimulated atherosclerosis remains to be elucidated. We investigated the effects of acipimox
Inflammation and lipid accumulation in xanthoma disseminatum: Therapeutic considerations.
Klaus Eisendle et al.
Journal of the American Academy of Dermatology, 58(2 Suppl), S47-S49 (2008-01-23)
Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.
Vaag A, et al.
The Journal of Clinical Investigation, 88(4), 1282-1290 (1991)
Lars C Gormsen et al.
European journal of endocrinology, 154(5), 667-673 (2006-04-29)
Concentrations of the orexigenic peptide ghrelin is affected by a number of hormones, which also affect circulating levels of free fatty acids (FFAs). The present study was therefore designed to determine the direct effect of FFAs on circulating ghrelin. Eight
Jara Nedvidkova et al.
Regulatory peptides, 167(1), 134-139 (2011-01-18)
Ghrelin is predominantly produced by the stomach and the growth hormone (GH)-ghrelin feedback loop between the stomach and the pituitary gland has recently been suggested. The disruption of the gut-brain axis might be involved in bulimia nervosa (BN). We investigated
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