399275

N^ω-Hydroxy-nor-L-arginine, Diacetate Salt

A potent, selective, competitive, and high affinity inhibitor of arginase.

• Sinónimos: N^ω-Hydroxy-nor-L-arginine, Diacetate Salt, nor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H
• Fórmula empírica (notación de Hill): C₅H₁₂N₄O₃ · 2C₂H₄O₂
• Número de CAS: 189302-40-7
• Peso molecular: 296.28
• UNSPSC Code: 12352209
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥97% (TLC)
• form: solid
• potency: 2 μM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: off-white
• solubility: water: 50 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Descripción

General description

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC₅₀ = 2 µM) and mouse macrophages (IC₅₀ = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC₅₀ = 2 µM) and mouse macrophages (IC₅₀ = 50 µM). Specifically interacts with the manganese-cluster of the enzyme active site. Does not act as a substrate or as an inhibitor of NOS. Hence, it may serve as a useful tool to study the interplays between arginase and NOS.

Biochem/physiol Actions

Primary Target
arginase from rat liver

Secondary Target
mouse macrophages (IC₅₀ = 50 µM)

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
Moali, C., et al. 2000. Biochemistry 39, 8208.
Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
Moali, C., et al. 1998. Biochemistry 37, 10453.
Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable