1.07185

Pepsin

(from porcine gastric mucosa) 0.7 FIP-U/mg for biochemistry EC 3.4.23.1

• Sinónimos: Pepsin
• Número de CAS: 9001-75-6
• Peso molecular: 35000
• MDL number: MFCD00081840
• UNSPSC Code: 12352204
• EC Index Number: 232-629-3
• NACRES: NA.21

Propiedades

• pH: 4.0-5.0 (20 °C, 10 g/L in H₂O)
• solubility: 10 g/L
• bulk density: 380‑420 kg/m³
• storage temp.: 2-30°C

Descripción

Application

Pepsin has been used in the preparation of simulated gastric fluid to perform in vitro gastric digestion.

Biochem/physiol Actions

Pepsin is a component of gastric juice and is associated with protein digestion. It is an endopeptidase that catalyzes the degradation of proteins into peptides and amino acids for small intestinal absorption. Pepsin is released as a zymogen (pepsinogen) by the chief cells of the gastric lining. It gets activated by the acidic environment created by the hydrochloric acid (HCl) of gastric juice. Pepsin is active at pH 1.5 to 2, in the stomach. It is involved in the conversion of food bolus into chyme. It is associated with laryngopharyngeal reflux (LPR) indicated by chronic cough, mild dysphagia, hoarseness, and non-productive throat clearing.

Analysis Note

Appearance: fine, slightly yellow powder
Activity/FIP (Hemoglobin; pH 1.6; 25 °C): ≥ 0.70 FIP-U/mg
pH-value (1 %; water): 4.0 - 5.0
Water (according to Karl Fischer): ≤ 6.0 %

Información de seguridad

• pictograms: GHS07,GHS08
• signalword: Danger
• hcodes: H315 - H319 - H334 - H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable