B-024

Butabarbital solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Fórmula empírica (notación de Hill): C₁₀H₁₆N₂O₃
• Número de CAS: 125-40-6
• Peso molecular: 212.25
• UNSPSC Code: 41116107
• PubChem Substance ID: 329773103
• NACRES: NA.24

Propiedades

• grade: certified reference material
• form: liquid
• feature: SNAP-N-SPIKE^®, SNAP-N-SHOOT^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• drug control: Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• concentration: 1.0 mg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): forensics and toxicology
• format: single component solution
• storage temp.: −20°C
• SMILES string: O=C(NC(C1(CC)C(C)CC)=O)NC1=O
• InChI: 1S/C10H16N2O3/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15)
• InChI key: ZRIHAIZYIMGOAB-UHFFFAOYSA-N
• Gene Information: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

Descripción

General description

Butabarbital is a barbiturate prescribed as a sleep aid under the trade name Butisol. sold under the name Butisol as a sleep aid. This analytical reference material is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, or urine drug testing.

Application

• Propranolol-D7 labeled solution: (±)-Propranolol-D₇ used in the analysis of β-blockers and metabolites in milk powder, employing high-performance liquid chromatography coupled to quadrupole Orbitrap high-resolution mass spectrometry. This application underscores the compound′s utility in sophisticated bioanalytical assessments, crucial for understanding pharmacokinetic behaviors in diverse matrices (Cheng et al., 2019).


• Stable isotope-labeled propranolol for bioanalysis: Propranolol-D₇ used as an internal standard in a simultaneous determination method for propranolol and its metabolite in human plasma. The method, utilizing solid phase extraction and liquid chromatography/electrospray tandem mass spectrometry, highlights the role of stable isotopes in enhancing the precision and reliability of pharmacokinetic studies (Partani et al., 2009).


• Propranolol-D₇ tracer for pharmacokinetic studies: (±)-Propranolol-D₇ employed in an innovative technique combining laser microdissection and liquid vortex capture-mass spectrometry for absolute quantitation of propranolol in thin tissue sections. This method allows for precise measurement of drug distribution in small, spatially distinct regions, enhancing the understanding of drug dynamics within organs (Cahill et al., 2016).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 49.5 °F - closed cup
• flash_point_c: 9.7 °C - closed cup