KITALYSIS-BOR

KitAlysis^™ High-Throughput Miyaura Borylation Reaction Screening Kit-Pack of 2

• UNSPSC Code: 12161600
• NACRES: NA.21

Propiedades

• reaction suitability: reagent type: catalyst; core: palladium; reaction type: Miyaura Borylation Reaction
• functional group: phosphine

Descripción

General description

The KitAlysis High-Throughput Miyaura Borylation Reaction Screening Kit enables chemists to quickly and efficiently screen reaction conditions for Pd catalyzed Miyaura borylation reactions. Quick identification of optimal conditions allows faster scale-up of the desired synthetic transformation. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.

Application

Step-by-step user guides and a downloadable experimental excel sheets are provided in the below hyperlinks.
Step-by-Step Guide for Miyaura Borylation Reaction Screening Kit
Downloadable Experiment excel sheets

Each kit contains 2 customizable screening sets that include the following components:

• 6 x 4 pre-weighed catalysts in glass vials loaded with stir bars and topped with cap mat.
• 4 x 4 mL reaction vials with pre-weighed KOAc
• Bis(pinacolato)diboron (473294), tetrahydroxydiboron (754242), and pinacol (221171)
• 1 (2 mL) ampule each of toluene, THF, n-butanol, DMA, MeOH, MeCN, ethylene glycol and DIPEA.
• 1 NEW KitAlysis 24-Well Reaction Block Replacement Film.
• 4 stir bars for substrate stock solution vials.
• 1 internal standard.

Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

• Designed and tested by synthetic chemists.
• Easily run 24-microscale reactions in parallel.
• 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration.
• Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks.

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Los componentes del kit también están disponibles por separado

• 764175 P(Cy₃) Pd G3, 97%
• 791733 Potassium acetate, anhydrous, free-flowing, Redi-Dri^™, ACS reagent, ≥99.0%
• 804274 XPhos Pd G4, 95%
• 804282 SPhos Pd G4
• 804290 RuPhos Pd G4
• 804975 DTBPF-Pd-G3
• 900349 cataCXium Pd G4
900522 Toluene, anhydrous, ZerO₂^®, 99.8%
900631 Ethylene glycol, anhydrous, ZerO₂^®, 99.8%
900634 N,N-Dimethylacetamide, anhydrous, ZerO₂^®, 99.8%
900636 Tetrahydrofuran, anhydrous, inhibitor-free, ZerO₂^®, ≥99.9%
900639 1-Butanol, anhydrous, ZerO₂^®, 99.8%
900641 Methanol, anhydrous, ZerO₂^®, 99.8%
900644 Acetonitrile, anhydrous, ZerO₂^®, 99.8%
900690 N,N-Diisopropylethylamine, purified by redistillation, ZerO₂^®, 99.5%
221171 Pinacol, 98%
473294 Bis(pinacolato)diboron, 99%
754242 Tetrahydroxydiboron, 95%
B34656 Biphenyl, ReagentPlus^®, 99.5%
Z118850 Spinbar^® magnetic stirring fleas, red, L 10 mm, diam. 3 mm
Z742110 KitAlysis^™ 24-well reaction block replacement film

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Información de seguridad

• pictograms: GHS02,GHS06,GHS08,GHS05,GHS09
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H315,H318,H335,H336,H351,H360D,H370,H373,H410
• pcodes: P210 - P273 - P280 - P301 + P310 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Oral - STOT SE 1 - STOT SE 3
• target_organs: Central nervous system, Eyes,Central nervous system, Kidney, Respiratory system
• supp_hazards: EUH019
• Storage Class: 3 - Flammable liquids
• flash_point_f: 1.4 °F
• flash_point_c: -17 °C