902675

BocNH-PEG₆-acid

• Sinónimos: 2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid, Boc-NH-PEG6-CH₂COOH
• Fórmula empírica (notación de Hill): C₁₉H₃₇NO₁₀
• Número de CAS: 391684-36-9
• Peso molecular: 439.50
• MDL number: MFCD30489670
• UNSPSC Code: 12352106
• NACRES: NA.22

Propiedades

• form: liquid
• reaction suitability: reagent type: linker
• refractive index: n/D 1.4657
• functional group: Boc; amine; carboxylic acid
• storage temp.: −20°C
• SMILES string: OC(COCCOCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O

Descripción

Application

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG₆-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Other Notes

α_vβ₃ Integrin-Targeting Arg-Gly-Asp (RGD) Peptidomimetics Containing Oligoethylene Glycol

Ultrasmall particle of iron oxide-RGD peptidomimetic conjugate: synthesis and characterization

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable