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902551

Sigma-Aldrich

BocNH-PEG4-acid

Sinónimos:

2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid, Boc-NH-PEG4-CH2COOH

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About This Item

Fórmula empírica (notación de Hill):
C15H29NO8
Número de CAS:
876345-13-0
Peso molecular:
351.39
UNSPSC Code:
12352106
NACRES:
NA.22

form

liquid

reaction suitability

reaction type: Pegylations
reagent type: cross-linking reagent

refractive index

n/D 1.4641

density

1.1395 g/mL

functional group

Boc
amine
carboxylic acid

storage temp.

−20°C

SMILES string

OC(COCCOCCOCCOCCNC(OC(C)(C)C)=O)=O

Categorías relacionadas

Application

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Other Notes

A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications

A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Related product

Referencia del producto
Descripción
Precios

901830

Pomalidomide-PEG4-NH2 hydrochloride, ≥95%

901824

Pomalidomide-PEG4-CO2H

901848

(S,R,S)-AHPC-PEG4-NH2 hydrochloride, ≥95%

902683

BocNH-PEG5-acid

902675

BocNH-PEG6-acid

905208

Pomalidomide-C6-PEG3-butyl amine hydrochloride, ≥98%

907677

(S,R,S)-AHPC-PEG6-butyl chloride

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
MKCQ6700

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A biocompatible condensation reaction for the labeling of terminal cysteine residues on proteins.
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Zinc(II) cyclen-peptide conjugates interacting with the weak effector binding state of RaS.
Rosnizeck I C, et al.
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