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Merck

361518

Sigma-Aldrich

1-Hydroxypyrene

98%

Sinónimos:

1-Pyrenol

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About This Item

Fórmula empírica (notación de Hill):
C16H10O
Número de CAS:
Peso molecular:
218.25
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

98%

mp

179-182 °C (lit.)

SMILES string

Oc1ccc2ccc3cccc4ccc1c2c34

InChI

1S/C16H10O/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9,17H

InChI key

BIJNHUAPTJVVNQ-UHFFFAOYSA-N

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General description

1-Hydroxypyrene, as a urinary metabolite, is a marker of polycyclic aromatic hydrocarbons (PAH) exposure. 1-Hydroxypyrene is an important biomarker of exposure to pyrene.

Application

1-Hydroxypyrene is suitable for use in following studies:
  • To investigate the fast detection and quantification of 1-hydroxypyrene in tissue extracts from Nereis diversicolor exposed to sediment-associated pyrene by a simple fluorometric method.
  • To investigate the effects of genetic polymorphisms of the cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1) and glutathione S-transferases mu (GSTM1) and theta (GSTT1) on urinary 1-hydroxypyrene and 2-naphthol levels in aircraft maintenance workers.
  • To examine the the PAH exposure of cokery workers in an Estonian oil shale processing plant.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Anders M B Giessing et al.
Marine environmental research, 56(5), 599-615 (2003-08-21)
The uptake of polycyclic aromatic hydrocarbons (PAHs) by marine deposit-feeding invertebrates can be determined by screening for PAH-derived metabolites. We identified 1-hydroxypyrene as the only intermediate metabolite in tissue of four species of deposit-feeding polychaetes, Nereis diversicolor, Nereis virens, Arenicola
F J Jongeneelen
Toxicology letters, 72(1-3), 205-211 (1994-06-01)
A biomarker of human exposure to chemical agents provides a valuable parameter for assessing the extent and significance of the uptake by giving a measurement that is direct and integrated over time and exposure routes. Urinary 1-hydroxypyrene is currently tested
Christiana A Demetriou et al.
Occupational and environmental medicine, 69(9), 619-627 (2012-07-10)
The association between ambient air pollution exposure and lung cancer risk has been investigated in prospective studies and the results are generally consistent, indicating that long-term exposure to air pollution may cause lung cancer. Despite the prospective nature and consistent
Laura Campo et al.
International journal of environmental research and public health, 15(6) (2018-06-06)
Active smoking is associated with increased body burden of polycyclic aromatic hydrocarbons (PAHs); the aim of this study was to assess whether environmental tobacco smoking (ETS) increases the internal dose of PAHs. In 344 nonsmoking Italian adults, out of 497
Ase M Hansen et al.
International journal of hygiene and environmental health, 211(5-6), 471-503 (2008-01-29)
A total of 132 studies were identified, of which 25 studies addressed environmental exposure to polycyclic aromatic hydrocarbons (PAHs) in the general population. Of these 9 studies included children. Of 101 studies among workers in various occupations, 32 studies were

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