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V4512

Sigma-Aldrich

Vascular Endothelial Growth Factor from mouse

VEGF, recombinant, expressed in E. coli, powder, suitable for cell culture

Synonym(s):

mVEGF, VEGF

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About This Item

MDL number:
MFCD01636149
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

mouse

Quality Level

100

recombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE)

form

powder

potency

≤10 ng/mL

quality

endotoxin tested

mol wt

protein 39 kDa

packaging

pkg of 10 μg
pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

<1 EU/μg

UniProt accession no.

Q00731

storage temp.

−20°C

Gene Information

mouse ... VEGFA(22339)

General description

Vascular endothelial growth factor is also known as VPF, VEGF and MVCD1. It is secreted from endothelial cells and pericytes in response to hypoxia. It helps in inducing angiogenesis and microvascular hyperpermeability. VEGF levels are associated with vasculitic neuropathy and may be used to predict this disease. It may also act as a marker in the development and progression of early precancerous lesions of oesophagus.

Application

Vascular endothelial growth factor (VEGF) supports development of new blood vessels during embryonic development and after vascular injury.Vascular endothelial growth factor from mouse was used for ELISA and in matrigel plugs (matrigel was supplemented with VEGF).

Other Notes

Homodimeric protein consisting of two 165 amino acid polypeptide chains of mouse VEGF.
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Physical form

Lyophilized from a 0.2 μm filtered buffered solution.

Analysis Note

The biological activity is measured by the ability to stimulate 3H-thymidine incorporation in human umbilical vein endothelial cells (HUVEC) and bovine aortic endothelial cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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J Sundaram et al.
Journal of thrombosis and haemostasis : JTH, 12(5), 690-700 (2014-07-01)
Recent studies have shown that factor VIIa binds to endothelial cell protein C receptor(EPCR), a cellular receptor for protein C and activated protein C. At present, the physiologic significance of FVIIa interaction with EPCR in vivo remains unclear. To investigate
Katsuhisa Tashiro et al.
Stem cells and development, 23(18), 2202-2210 (2013-12-19)
Vascular endothelial growth factor (VEGF) is reported to exhibit potent hematopoietic stem/progenitor cell (HSPC) mobilization activity. However, the detailed mechanisms of HSPC mobilization by VEGF have not been examined. In this study, we investigated the effect of VEGF on bone
Asieh Golozar et al.
European journal of cancer (Oxford, England : 1990), 50(16), 2855-2865 (2014-08-31)
Mechanisms involved in wound healing play some role in carcinogenesis in multiple organs, likely by creating a chronic inflammatory milieu. This study sought to assess the role of genetic markers in selected inflammation-related genes involved in wound healing (interleukin (IL)-1a
Benjamin B Bartelle et al.
Circulation research, 110(7), 938-947 (2012-03-01)
The formation and maintenance of a functional vasculature is essential for normal embryonic development, and genetic changes that affect the vasculature underlie pathogenesis in many human diseases. In vivo imaging in mouse models is required to understand the full complexity
Jafar Rezaie et al.
Journal of cellular biochemistry, 119(1), 524-535 (2017-06-14)
This experiment investigated the impact of serum from patients with type 2 diabetes mellitus on the angiogenic behavior of human mesenchymal stem cells in vitro. Changes in the level of Ang-1, Ang-2, cell migration, and trans-differentiation into pericytes and endothelial
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Articles

Vascular Endothelial Growth Factors (VEGF)

Vascular endothelial growth factor (VEGF) is a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGF-A (VEGF) is a potent growth factor for blood vessel endothelial cells, showing pleiotropic responses that facilitate cell migration, proliferation, tube formation, and survival. In the developing embryo VEGF-A mRNA is expressed by cells within tissues undergoing capillarization.

VEGF Pathway

Read review on VEGF signaling pathway (Vascular endothelial growth factor (VEGF)/VEGF receptor) and find related products.

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