K2644

Kisspeptin-234 trifluoroacetate salt

≥95% (HPLC)

• Synonym(s): kisspeptin-10 peptide 234
• Empirical Formula (Hill Notation): C₆₃H₇₈N₁₈O₁₃ · xC₂HF₃O₂
• CAS Number: 1848962-29-7
• Molecular Weight: 1295.41 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: film
• color: colorless to white
• solubility: H₂O: >1 mg/mL
• storage temp.: −20°C

Description

Biochem/physiol Actions

Kisspeptin-234 is a 10-amino acid peptide antagonist with potent neutral antagonist activity at GPR-54 and competes directly at the Kisspeptin-10 binding site. Kisspeptin-234 is the first reported antagonist for the kisspeptin-1/GPR-54 signaling system.

Gonadotropin-releasing hormone (GnRH) modulates the hypothalamic-pituitary-gonadal axis, enabling the brain to control reproductive processes. Kisspeptin-1 is a peptide neurotransmitter released from afferent neurons onto GnRH neurons, where it binds to and activates to the orphan receptor GPR-54 to regulate release of GnRH. Regulation of kisspeptin/GPR-54 signaling presents an opportunity for reproductive therapeutics above the level of GnRH and gonadotropin secretion. Pharmacological and selective tools are needed to better understand kisspeptin-1/GPR-54 signaling. Analogs of kisspeptin-10, a 10-amino acid portion of kisspeptin-1, were designed to be full and neutral antagonists of GPR-54.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable