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729159

Sigma-Aldrich

Poly(ethylene glycol) methyl ether thiol

average MN 6,000, chemical modification reagent thiol reactive, methoxy, thiol

Synonym(s):

Polyethylene glycol, Methoxy PEG thiol, Methoxypolyethylene glycol thiol, PEG thiol, mPEG thiol

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About This Item

Linear Formula:
CH3O(CH2CH2O)nCH2CH2SH
UNSPSC Code:
12162002
NACRES:
NA.23

product name

Poly(ethylene glycol) methyl ether thiol, average Mn 6,000

form

solid

Quality Level

100

mol wt

average Mn 6,000

reaction suitability

reagent type: chemical modification reagent
reactivity: thiol reactive

mp

56-61 °C

Mw/Mn

≤1.2

Ω-end

thiol

α-end

methoxy

polymer architecture

shape: linear
functionality: monofunctional

shipped in

dry ice

storage temp.

−20°C

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General description

Poly(ethylene glycol) methyl ether thiol (mPEGthiol) is a thiol-terminated biocompatible polymer widely used in the surfacefunctionalization of gold nanoparticles. Thiol moieties bind with high affinityto gold surfaces by forming a self-assembled monolayer (SAM) through thecovalent thiolate–metal bond. mPEG thiol-coated Au nanoparticles findapplication in the fields of biosensors and drug delivery systems.

Application

Poly(ethylene glycol) methyl ether thiol-coated Au nanoparticles can be used for the determination of melamine T. by an optical method. It can also be used to fabricate switchable super-wetting membranes foroil/water separation.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCL4582
MKCH0719
MKCF5112
MKBW7623V
MKBS3186V

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Amina Ghorbel et al.
Bioelectrochemistry (Amsterdam, Netherlands), 137, 107642-107642 (2020-09-28)
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Antibody-coated nanoparticles have recently attracted considerable attention, with the focus falling on diagnostics. Nevertheless, controlled antibody bioconjugation remains a challenge. Here, we present two strategies of bioconjugation with the aim of evaluating the best approach for the coupling of antibodies

Articles

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds via Bio-orthogonal Click Reactions

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

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