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729108

Sigma-Aldrich

Poly(ethylene glycol) methyl ether thiol

average MN 800, chemical modification reagent thiol reactive, methoxy, thiol

Synonym(s):

Polyethylene glycol, Methoxy PEG thiol, Methoxypolyethylene glycol thiol, PEG thiol, mPEG thiol

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About This Item

Linear Formula:
CH3O(CH2CH2O)nCH2CH2SH
UNSPSC Code:
12162002
NACRES:
NA.23

product name

Poly(ethylene glycol) methyl ether thiol, average Mn 800

form

solid

mol wt

average Mn 800

reaction suitability

reagent type: chemical modification reagent
reactivity: thiol reactive

impurities

≤10% disulfide

transition temp

Tm 32-37 °C

Mw/Mn

≤1.1

Ω-end

thiol

α-end

methoxy

polymer architecture

shape: linear
functionality: monofunctional

storage temp.

2-8°C

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Application

Poly(ethylene glycol) methyl ether thiol can be used to functionalize Fe3O4@Au core-shell nanoparticles. The thiolated PEG increases the water solubility and significantly lowers the nanotoxicity.

It can be used as a precursor to synthesize PEG conjugated poly(β-amino ester) polyplexes for gene therapy.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
MKCJ5643
MKCF9838
MKCD1865
MKBX2632V
MKBT7893V

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Cristina Gentilini, Mariangela Boccalon, and Lucia Pasquato
The Journal of Organic Chemistry, 3308-3308 (2008)
Nisha C. Kalarickal, Stephen Rimmer, Prodip Sarker, and Jean-Christophe Leroux
Macromolecules, 40, 1874-1874 (2007)

Articles

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds via Bio-orthogonal Click Reactions

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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