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Merck
모든 사진(1)

주요 문서

1225281

USP

Dorzolamide hydrochloride

United States Pharmacopeia (USP) Reference Standard

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About This Item

실험식(Hill 표기법):
C10H16N2O4S3 · HCl
CAS Number:
Molecular Weight:
360.90
Beilstein:
5896026
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24

Grade

pharmaceutical primary standard

API family

dorzolamide

제조업체/상표

USP

응용 분야

pharmaceutical (small molecule)

형식

neat

SMILES string

Cl.CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O

InChI

1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1

InChI key

OSRUSFPMRGDLAG-QMGYSKNISA-N

유전자 정보

human ... CA2(760)

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일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

Dorzolamide hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution
  • Dorzolamide Hydrochloride Ophthalmic Solution

분석 메모

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

기타 정보

Sales restrictions may apply.

픽토그램

Health hazardExclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Oral - STOT RE 2

표적 기관

Central nervous system,Gastrointestinal tract,Bone,Blood,Bladder

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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이미 열람한 고객

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1 of 1

M F Sugrue
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 12(3), 363-376 (1996-01-01)
Dorzolamide hydrochloride (S,S-5,6-dihydro-4H-4-ethylamino-6-methylthieno [2,3-b]thiopyran-2-sulfonamide-7,7-dioxide HCl; MK-507; L-671,152) is a water-soluble, potent inhibitor of human carbonic anhydrase isoenzymes II and IV in vitro, the respective IC50 values being 0.18 nM and 6.9 nM. In contrast, it was found to be a
Göktuğ Seymenoğlu et al.
Journal of glaucoma, 24(2), 111-116 (2013-06-29)
To compare the efficacy of fixed combinations of dorzolamide-timolol (FCDT) and brimonidine-timolol (FCBT) in patients with intraocular pressure (IOP) elevations after intravitreal triamcinolone acetonide (IVTA) injections. This was a prospective, randomized, open-label study. Patients who received IVTA injections due to
Masamichi Fukuda et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 31(1), 57-60 (2014-10-11)
We investigated the transcorneal penetration of commercial ophthalmic formulations containing timolol maleate in rabbit eyes. One drop (30 μL) of each ophthalmic solution (Xalacom(®), DuoTrav(®), Cosopt(®), and Timoptol(®)) was administered to the conjunctival sac of the rabbits' eyes and the
Azza A Hasan
Pharmaceutical development and technology, 19(6), 748-754 (2013-08-24)
The objective of this work was to formulate and characterize non-ionic surfactant vesicles (niosomes) as an ocular carrier of dorzolamide hydrochloride (Dorzo); one of the antiglaucoma drugs. Niosomes were prepared of Cholesterol (Chol) with sorbitan monoesters (Span 20, 40, 60)

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