PHL86198

Piperlongumine

phyproof^® Reference Substance

• 동의어(들): 5,6-Dihydro-1-(1-oxo-3-[3,4,5-trimethoxyphenyl]-trans-2-propenyl)-2[1H]-pyridinone, 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-Pyridinone, Piplartin, Piplartine
• 실험식(Hill 표기법): C₁₇H₁₉NO₅
• CAS Number: 20069-09-4
• Molecular Weight: 317.34
• MDL number: MFCD00075706
• UNSPSC 코드: 12352100
• NACRES: NA.24

속성

• Grade: primary reference standard
• 제품 라인: phyproof^® Reference Substance
• 분석: ≥90.0%
• 제조업체/상표: PhytoLab
• 응용 분야: food and beverages; pharmaceutical
• 저장 온도: 2-8°C
• SMILES string: COc1cc(\C=C\C(=O)N2CCC=CC2=O)cc(OC)c1OC
• InChI: 1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+
• InChI key: VABYUUZNAVQNPG-BQYQJAHWSA-N

설명

일반 설명

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

생화학적/생리학적 작용

Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). It increases the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells with little effect on either rapidly or slowly dividing primary normal cells. Piperlongumine showed significant antitumour effects in a variety of mouse tumour models and inhibited growth of spontaneously formed malignant breast tumours and their associated metastases.

법적 정보

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable